Low Progesterone Symptoms in Females There are some classic signs of low progesterone: Irregular Menstrual Cycles Progesterone is the main hormone responsible for regulating your cycle. Typical menstrual cycles are about 28 days long. If your cycle is much longer, shorter, or unpredictable then this could be due to low progesterone. Infertility If you have trouble … Continue reading Seven Symptoms of Low Progesterone in Women