PCOS Subtypes May be Genetic
A recent study proposed a new categorization for type of PCOS based on genetic markers. The researchers then categorized women who had PCOS into 3 different groups based on their hormonal profiles and genetic markers. These groups were (5):
- Reproductive group – higher LH & SHBG, but lower BMI, insulin, & glucose levels
- Metabolic group – higher BMI, insulin, & glucose levels, with relatively low SHBG and LH levels
- Indeterminate – did not neatly fit into either group
About 40% of women did not fit clearly into the reproductive group or the metabolic group because the values measured were between those of the reproductive and metabolic subtypes. Women with the reproductive subtype were significantly more likely to carry a genetic variation affecting androgen production in the ovaries.
Related: PCOS, Integrative Treatments, & Improving Fertility
Identifying Your PCOS Type
Recognizing your unique PCOS subtype is a helpful first step toward effective management. Here’s how you can identify your type through symptoms and diagnostic tests:
Symptom Analysis
- Insulin-Resistant PCOS: Look for signs of weight gain, skin tags, dark patches of skin (acanthosis nigricans), and irregular periods.
- Inflammatory PCOS: Be aware of chronic fatigue, skin issues, joint pain, and gut health problems.
- Adrenal PCOS: Notice if you have persistent anxiety, high stress levels, and menstrual irregularities.
- Post-Pill PCOS: Pay attention to breakouts, hair shedding, and cycle changes after stopping birth control pills.
Diagnostic Tests
Consult a healthcare provider for comprehensive diagnostic tests:
- Blood Tests: Measure insulin, fasting blood glucose, and androgen levels.
- Ultrasound: Check for the presence of cysts on the ovaries.
- Inflammation Markers: Assess CRP levels for inflammatory PCOS.
- Hormone Panels: Evaluate DHEA-S levels for adrenal PCOS.
Contact a patient care coordinator now to discuss hormone testing options.
What If Your PCOS Does Not Match a Type?
Unfortunately, misdiagnosis and delayed diagnosis are not uncommon when women experience reproductive & metabolic disorders like PCOS. There are also other health conditions that may mimic PCOS, but are not.
Hypothalamic amenorrhea (HA) causes missing periods due to low levels of GnRH, a hormone made in the hypothalamus that regulates the reproductive system. Severe under-eating, excessive exercise or stress, low body fat, and other factors that affect the hypothalamus are among the root causes for hypothalamic amenorrhea. HA symptoms may overlap with PCOS. It’s possible to have both HA and PCOS, but HA can exclude a PCOS diagnosis.
Similarly, a low or underactive thyroid (hypothyroid) can also cause irregular cycles and lack of ovulation. The bottom line: if your period is irregular or missing completely, it’s crucial to work with an integrative team who will guide you to identify and address the root cause.
Integrative Medicine Approaches for PCOS
Integrative medicine combines conventional treatments with alternative therapies to address the root causes of PCOS. Here are some effective approaches:
Lifestyle Modifications
- Exercise: Regular physical activity helps improve insulin sensitivity and reduce inflammation.
- Stress Management: Techniques like yoga, meditation, and deep-breathing exercises can lower stress hormones.
Dietary Changes
- Low-Glycemic Diet: Focus on whole foods, lean proteins, and healthy fats to manage insulin levels.
- Anti-Inflammatory Foods: Incorporate turmeric, ginger, and omega-3 fatty acids to combat inflammation.
- Balanced Meals: Ensure your diet includes a variety of nutrients to support overall health & support healthy blood sugar.
Holistic Therapies
- Acupuncture: Can help regulate menstrual cycles and reduce stress.
- Herbal Supplements: Herbs like inositol, spearmint tea, and chasteberry may improve symptoms.
- Nutritional Supplements: Consider vitamins D and B12, magnesium, and omega-3s to replenish nutrients.
Expert Insights
Dr. Taz, our founder and double board certified physician in women’s health and integrative medicine, shares her insights on managing PCOS. According to Dr. Taz, “Many patients often go misdiagnosed for a period of time, because they don’t fit the classical textbook picture that is taught in medical school; grossly overweight, balding and with acne. Most patients I meet, including myself, have a more subtle version of these extremes.”
When treating PCOS, she believes it’s crucial to assess patients as an individual—there is no one-size-fits-all when it comes to PCOS treatment.
For PCOS solutions tailored to your unique chemistry, contact us to get started.
What to Remember
Understanding the subtype of PCOS you have can be incredibly useful in helping you and your integrative healthcare team effectively manage your PCOS symptoms. However, there are some cases of PCOS that may not fit neatly into one of these subtypes. It’s essential to work closely with your healthcare provider to develop a personalized treatment plan that addresses all of your individual needs.
With the right approach, it is possible to live well with PCOS and thrive in all aspects of life.