Unveiling the Anti-Aging Power of NAD+

In the quest for timeless beauty, a molecule is gaining the spotlight—

Aging is a natural process that we all have to go through, but most of us want to delay its visible effects for as long as possible. While foundational practices like a healthy diet, sleep, and stress reduction are key to looking and feeling youthful in holistic dermatology, there are ways to maximize their potential.

That's where molecules like NAD+ come in.

Let's dive into the science behind NAD+, its role in skin aging, and how you can harness its anti-aging prowess.

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What is NAD+?

Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme found in every cell of the body. Its primary function is to facilitate cellular energy production. NAD+ is crucial for many processes in our body, including metabolism, DNA repair, and gene expression.

NAD+ is made in the body using amino acids like tryptophan, and precursors like nicotinamide, or vitamin B3.

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NAD+ Decreases with Age

As we age, our NAD+ levels decrease, slowing cellular energy and increasing the signs and symptoms of aging. This decline happens as a result of a combination of factors, including oxidative damage, illness, environmental stressors, and chronic inflammation—which are important to address with holistic dermatology (1). 

Low levels of NAD+ then leads to UV sensitivity and impaired DNA damage response. NAD+ depletion is also associated with skin aging and cancer (2). With increased biological age, and as our NAD+ levels decline, so does cellular health, which can result in visible signs of aging like wrinkles and loss of skin elasticity.

Read: Boost Cellular Health with Liposomal Glutathione

The Role of NAD+ in Skin Health

So, how exactly does NAD+ affect the skin? Holistic dermatology has unveiled the profound impact of NAD+ on the aging process and cellular health.

Collagen Boost

Collagen, the protein responsible for skin firmness, is positively influenced by NAD+. Studies suggest that NAD+ may enhance collagen production, contributing to smoother and more (2) youthful-looking skin. 

Wrinkle Reduction

NAD+ has demonstrated the potential to reduce the appearance of wrinkles by promoting cellular repair mechanisms and supporting skin elasticity.

Several studies have shown that NAD+ can help reduce visible signs of aging in the skin with the help of holistic dermatology, such as wrinkles, fine lines, and dark spots. NAD+ status in skin cells appears to mitigate some of the effects of oxidative stress & photoaging, because of its effect on stem cells, skin cell turnover, and DNA integrity.

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Hydration and Firmness

NAD+ supports cellular hydration and helps maintain skin firmness by boosting levels of collagen, keratin, elastin, and hyaluronic acid (1). 

NAD+ also plays a role in promoting skin hydration and reducing hyperpigmentation. One study found that NAD+ can increase the production of ceramides, which are lipids that help to retain moisture in the skin (3). This can help to keep the skin looking plump and youthful.

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May protect against skin cancer

NAD+ depletion with age or following UV radiation may play a major role in skin cancer by impairing processes involved in gene stability. Thus, the maintenance of adequate NAD+ levels is important for skin cancer prevention. In holistic dermatology, sun protection is paramount to maintaining healthy, youthful-looking skin.

Over the course of 12 months, one study found oral supplementation with nicotinamide (and NAD+ precursor) reduced skin cancer by 23% (4). Additionally, NAD+ can also help reduce hyperpigmentation, a common complaint associated with premature aging of the skin (2)

Read: Reduce Skin Cancer Risk—Sun Protection & SPF Guide

Other Health Benefits of NAD+

The role of NAD+ isn’t just important for skin health, but has many other implications for aging-related diseases, including those that affect the heart, brain, and skin—the body’s most metabolically active tissues.

NAD+ may support healthy aging by (1,5,6):

  • Helping to improve brain function and cognitive health
  • Supporting cellular functions, energy production, and vitality
  • Improving healing post-surgery 
  • Enhancing sleep quality

How to Increase NAD+ Levels

You can boost your levels of cellular NAD+ to reduce the visible signs of aging and support cellular energy using supplements, certain skin care productions, and by reducing activities that result in NAD+ decline.

Supplementation: NAD+ itself is not absorbed well by the digestive system, so supplementation is not beneficial. However, studies show that supplementation of 200 mg nicotinamide, a form of vitamin B3, increases blood NAD+ levels (7). 

Topical Application: Some skincare products harness the potential of NAD+ for topical application. Look for serums or creams containing NAD+ to incorporate into your skincare routine.

Lifestyle Practices: Certain lifestyle practices can slow NAD+ decline. Regular exercise, a balanced diet rich in NAD+-precursor foods like fish, nuts, and green vegetables, and proper sleep are integral for optimal NAD+ production. Getting adequate sleep and reducing stress have been shown to increase NAD+ levels.

The Future of NAD+ in Anti-Aging

As the science behind NAD+ unfolds, it’s evident that this microscopic coenzyme holds remarkable potential in the realm of anti-aging. From reducing wrinkles to promoting collagen production and maintaining skin hydration, NAD+ emerges as a multifaceted ally in our pursuit of youthful skin.

Whether through supplementation, topical application, or lifestyle practices, integrating NAD+ into our skincare routine could be a transformative step towards radiant and age-defying skin.

While taking NAD+ supplements or using topical products may be helpful, it is also important to adopt healthy lifestyle habits to increase your own production of NAD+.


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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases.
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